Overactivation of NMDA receptors in ammonia neurotoxicity: a target for neuroprotection?
نویسنده
چکیده
not submitted. Antiepileptic drugs and neuroprotection
منابع مشابه
The NMDA receptor antagonist memantine as a symptomatological and neuroprotective treatment for Alzheimer's disease: preclinical evidence.
There is increasing evidence for the involvement of glutamate-mediated neurotoxicity in the pathogenesis of Alzheimer's disease (AD). We suggest that glutamate receptors of the N-methyl-D-aspartate (NMDA) type are overactivated in a tonic rather than a phasic manner in this disorder. This continuous mild activation may lead to neuronal damage and impairment of synaptic plasticity (learning). It...
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تاریخ انتشار 2006